FUW TRENDS IN SCIENCE & TECHNOLOGY JOURNAL
(A Peer Review Journal)
e–ISSN: 2408–5162; p–ISSN: 2048–5170
keywords: Antioxidants,Nauclealatifolia, neutraceuticals, phytochemicals, reactive oxygen species
The phytochemical composition and anti-oxidant activities using Di-phenyl-1-picryl-hydrazyl (DPPH) Radical Scavenging assay, Ferric Reducing and Antioxidant Power(FRAP) and the Total Phenolic contents (TPC) of the extracts from the leaves, stem-bark and root of Nauclealatifolia.The phytochemical analysis revealed the presence of bioactive compounds in the entire plant samples. The leaves of Nauclealatifoliacontained tannins 0.17 g/100g, alkaloid 2.29 g/100g, 0.83 g/100g flavonoid and 0.56% saponin. The stem bark also contained 0.53, 2.58, 0.08 g/100g and 0.84% while the composition of the root are 0.13, 0.88, 0.32 g/100g and 0.72% tannins, alkaloids, flavonoids and saponin, respectively. The stem bark had the highest antioxidant potential; DPPH (30.60 mg/mL), FRAP (184.64 mg/GAE/g) and TPC (30.16 g/100g). Our findings provide evidence that the extract of Nauclealatifolia could be a potential source of natural antioxidants that may be used to combat stress related conditions.The phytochemical analysis supports the extensive use of the leaves bark and root of Nauclealatifoliain ethno-medicine in many parts of Africa. Overall, the result suggests that Nauclealatifolia could be a potential source of pharmacologically active natural product and/or for development of neutraceuticals.
Agoha RC 1981. Medical Plants of Nigeria. Offset DrukkerijiFaculted Der Wiskunde en Natuorwetens, Chappens, Nijimegen, Netherland, p 10. Anwar F, Jamil A, Iqbal S & Sheikh MA 2006. Antioxidant activity of various plant extracts under ambient and accelerated storage of sunflower oil,” GrasasyAceites, 57(2): 189 - 197. Akiyana H, Fuju K, Yamaski O, Ono T &Iwatsuki K 2011. Antibacterial action of several tannins against staphyloccusaureus.J. Antimicro. Chemotherapy, 48(4): 487-491. Ayeleso AO OguntibejuOO& Brooks NL 2014.In vitro study on the antioxidant potentials of the leaves and fruits of Nauclealatifolia.The Scientific World Journal, Article ID 437081, 8p.AtataRFSani A &Adewole SM 2005. Effects of stem bark extract of Enantiachlorantaon some clinical isolates. Biokemistri, 15(2): 84 – 92. BalunasMJ&Kinghorn AD 2005. Drug discovery from medicinal plants.Life Sciences, 78: 431-441. Basu S 2010. Fatty acid oxidation and isoprostanes: Oxidative strain and oxidative stress. Prostaglandins, Leukotrienes& Essential Fatty Acids, 82: 219-225. Benzie IFF& Strain JJ 1996. The ferric reducing ability of plasma (FRAP) as a measure of “antioxidant power”: The FRAP assay. Anal Biochem., 239: 70–76. Bernard S, Chang MD, Daniel H, Lowenstien MD. Mechanisms of disease epilepsy.The New England J. Medicine, 349: 1257–66. BöhmВA&Kocipai-Abyazan R 1994.Flavonoid and condensed tannins from leaves of Vaccinumraticulation&Vaccinumcalcyimium.Pacific Sciences, 48: 458-63. Coe FC & Anderson GJ 1996. Screening of Medicinal plants for bioactive compounds. J. Food Techn., 3(9): 429 – 431. CushnieTPT& Lamb AJ 2009.Antimicrobial activity of flavonoids.Int. J. Antimicro. Agent, 26(5): 343-356. DevasagayamTPATilakJCBoloorKK Sane KS Ghaskadbi SS &Lele RD 2004. Free radicals and antioxidants in human health: current status and future prospects. J. Assoc. Physicians of India, 52: 794–804. Donalisio M, Nana HM, Ngane RAN, Gatsing D, Tchinda AT, Rovito R, Cagno V, Cagliero C, BoyomFF, Rubiolo P, Bicchi C &Lembo D 2013. In vitro anti-Herpes simplex virus activity of crude extract of the roots of Nauclealatifolia Smith (Rubiaceae).BMC Complem.&Altern. Medicine, 13: 266. Egbung GE, AtangwhoIJ, Iwara IA, Odey MO &Ebong PE 2013.Chemical composition of root and stem bark extracts ofNauclealatifolia.Appl. Sci. Res., 5(3): 193-196. Eze SO & Ernest O 2014.Phytochemical and nutrient evaluation of the leaves and fruits of Nauclealatifolia (Uvuru-ilu).Communi.in Appl. Sci., 2(1): 8-24. FaleyeFJ&Akinwunmi OA 2016. Comparative nutritional compositions of the leaves, bark and root of Nauclealatifolia. J. Medical & Bio. Sci. Res., 2(7): 127-130. FarquarJW 1996. Plant sterols: their biological effects in humans. Handbook of Lipids in Human Nutrition: BOCA Rotan HrCRC Press, pp. 101-105. Gherraf N, Ladjel S, Labed B &Hameurlaine S 2011. Evaluation of antioxidant potential of various extracts of Traganumnudatumdel. Plant Sci. Feed, 1(9): 155-159. Giovannucci E 1998. Plant Bioactive Components: Phytochemistry. Bio. Res.,33: 159–165. HarborneJB 1973. Phytochemical Methods: A Guide to Modern Techniques of Plant Analysis. Chapman A & Hall, London, p. 279. James O &UgbedeHH 2011.Hypocholesterolemic effects of Nauclealatifolia(Smith) fruit studied in albino rats. Am. J. Tropical Medicine & Public Health, 1(1): 11–21. Khalaf NA, Shakya AK, Al-Othman A, El-Agbar Z & Farah H 2008. Antioxidant activity of some common plants.Turkish J. Bio., 32(1): 51–55. Khalid S, RizwanGH, Yasin H, Perveen R, Abrar H, Shareef H, Fatima K & Ahmed M 2013. Medicinal importance of Holoptelaintegrifolia(Roxb). Planch - Its biological and pharmacological activities. Natural Products Chem. & Res., 2(1): 1-4. Paul K, Jourma K, Ritva J, Harri H, Reunaner MA, Timo H &Arpo A 2012. Flavonoid intake and risk of chronic diseases.Amy Clinical Nutrition, 76(3): 560 – 568. Obadoni BO &Ochuko PO 2001.Phytochemical studies and comparative efficacy of the crude extracts of some homeostatic plants in Edo and Delta States of Nigeria.Global J. Pure & Appl. Sci., 8: 203-208. OjongLJ, Abdou JP, Kandeda AK, YayaAJG , Tchamgoue AD, TchokouahaLRY, Nkantchoua NGC, Agbor GA, Moyou RS & Ngo EB 2016. Anticonvulsant and in vitro antioxidant activities of MomordicaCissoidesL. (Cucurbitaceae).J. Appl. Pharmac. Sci., 4: 117-123. Okwu DE &Okwu ME 2004.Chemical composition of Spondiasmombinlinn plant parts.J. Sustainable Agric. &Envt.,6(2): 140-147. Omoyeni OA &AdeyeyeEI 2009.Chemical composition, calcium, zinc and phytate interrelationships in Aervalanata (Linn) Juss.exSchult leaves. Oriental J. Chem.,25(3): 485. Osunwole SA 1999.Traditional medicinal uses of selected plants on the University of Ibadan campus.The Nigr. Field, 64:168 – 173. Maizura M, Aminah A & Wan Aida WM 2011. Total phenolic content and antioxidant activity of kesum (Polygonum minus), ginger (Zingiberofficinale) and turmeric (Curcuma longa) extract. Int. Food Res. J., 18(2): 529-34. Nkafamiya II, ManjiAJ, ModibboUU&Umaru HA 2006.Biochemical evaluation of Cassipoureacongoensis(Tunti) and Nuclealatifolia(Luzzi) fruits.Afr. J. Biotech., 5(24): 2461–2463. NyaaTBL, Tapondjou AL, Barboni L, TamokouJDD, Kuiate JR, Tane P & Park HJ 2009. NMR assignment and Antimicrobial/antioxidant activities of 1β-hydroxyeuscaphic acid from the seeds of Butyrospermumparkii.NaturalProductSci., 15(2): 76À82. Pearson D 1976. The Chemical Analysis of Foods.3rd edition. Saeed N Khan MR&Shabbir M 2012. “Antioxidant activity, total phenolic and total flavonoid contents of whole plant extracts TorilisleptophyllaL. BMC Complem. &Altern. Medicine, 12: 221. Schrader M &Fahimi HD 2006.Peroxisomes and oxidative stress.BiochimBiophysActa, 1763: 1755-1766. Škrovánková S, Mišurcová L & Machu L 2012. Antioxidant activity and protecting health effects of common medicinal plants,” Advances in Food and Nutrition Research, 67: 75– 139. Suhaj M 2006. Spice antioxidants isolation and their antiradical activity: A review. J. Food Composition & Anal., 19(6): 531-537. TaïweGS, Bum EN, Talla E, Dimo T, Weiss N, Sidiki N, Dawe A, Okomolo Moto FC, DzeufietPD&Waard MD 2011. Antipyretic and antinociceptive effects of Nauclealatifolia root decoction and possible mechanisms of action. Pharmaceutical Biology 49(1): 15-25. Vinson JA Jang J Dabbagh YA Serry MM &Cai S 1995. Plant phenols exhibit lipoprotein-bound antioxidant activity using an in vitro model for heart disease. J. Agric & Food Chem., 43: 2798–2799.
